FRUCTOSE INDUCED HYPERURICEMIA PDF

Fructose-Induced Hyperuricemia Is Associated With a Decreased Renal Uric Acid Excretion in Humans. Virgile Lecoultre, PHD1,; Léonie Egli, MSC1,; Fanny. Fructose-induced hyperuricemia and hyperuricaciduria is associated with a striking increase in the blood lactate concentration, a decrease in erythrocyte. As such, we propose that the epidemic of the metabolic syndrome is due in part to fructose-induced hyperuricemia that reduces endothelial NO levels and.

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The serum Pi level decreased 2. Allopurinol, rutin, and quercetin attenuate hyperuricemia and renal dysfunction in rats induced by fructose intake: Open in a separate window.

Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is cructose altered.

No other potential conflicts of interest relevant to this article were reported. The lack of hyperruricemia in galactosemia patients after galactose ingestion may be explained by the observation that galactose is phosphorylated more slowly than fructose.

These studies support the hypothesis that fructose-induced hyperuricemia results from degradation of adenosine monophosphate. This article has been cited by other articles in PMC. F—F [ PubMed ]. This effect appears to be specific for fructose. In addition, we observed that a serum uric acid level above 5.

We recently reported that uric acid reduces levels of endothelial nitric oxide NOa key mediator of insulin action. Fructose–unlike other sugars–causes serum uric acid levels to rise rapidly. In two patients with hereditary fructose intolerance HFI the peak blood uric acid levels were Ingestion of a high-fructose meal increases blood uric acid UA concentration ffructose healthy subjects 1. Closed symbols represent data collected after 4—6 days of HFrD. Although the cumulative fructose load was large 1.

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As such, we propose that the epidemic of the metabolic syndrome is due in part to fructose-induced hyperuricemia that reduces endothelial Infuced levels and induces insulin resistance. Nutr Metab Lond ; 9: Author information Copyright and License information Disclaimer.

Fructose-Induced Hyperuricemia Is Associated With a Decreased Renal Uric Acid Excretion in Humans

The serum Pi levels decreased less in galactosemic patients after galactose administration than in patients with HFI after htperuricemia infusion. In two patients with HFI the uric acid excretion increased four- to fivefold after fructose administration; the increased uric acid excretion in HFI exceeded that of normal children.

Furthermore, high-fructose intake over several days is associated with increased fasting UA concentration 1.

Support Center Support Center. Parts of this study were presented in abstract form at Experimental BiologyBoston, Massachusetts, 20—24 April Blood glucose, lactic acid, and fructose levels were significantly increased after fructose, but serum magnesium levels did not change.

After the infusion of fructose, 0.

Fructose-Induced Hyperuricemia Is Associated With a Decreased Renal Uric Acid Excretion in Humans

The mean blood inorganic phosphate Pi levels were significantly less than the mean fasting value after fructose. In three patients with galactosemia, increases in blood uric acid levels after galactose ingestion were similar to those in normal children after fructose, but less than those in patients with HFI after fructose.

National Center for Biotechnology InformationU. This mechanism may substantially enhance the risk of gout in people who consume high amounts of sugar. It has not been assessed, however, whether UA also increases when fructose is administered as several small drinks instead of one single large load or whether a high-fructose diet HFrD impairs renal UA clearance UAC or fractional excretion UAFE as observed in rats 3.

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Am J Clin Nutr ; Please review our privacy policy. Acknowledgments This study was supported by grant from the Swiss National Foundation for Science and by a grant from Ajinomoto Co. NO increases blood flow to skeletal muscle and enhances glucose uptake.

Am J Physiol Renal Physiol ; Urinary UA excretion rate. Studies in humans should be performed to address whether lowering uric acid levels will help to prevent this condition. Effects of supplementation with essential amino acids on intrahepatic lipid concentrations during fructose overfeeding in humans. Because the metabolic effects of fructose show significant sex differences, it remains to be assessed whether the same effects are observed in female subjects.

This study was supported by grant from the Swiss National Foundation for Science and by a grant from Ajinomoto Co.

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Exercise prevents fructose-induced hypertriglyceridemia in healthy young subjects. These effects are generally attributed to an increased UA production, as inducfd after intravenous fructose administration 2.

These observations suggest that a decreased urinary UA excretion may contribute to fructose-induced hyperuricemia.