Kollicoat IR®, a new pharmaceutical excipient developed as a coating polymer for instant release tablets, was evaluated as a carrier in solid dispersions of. Kollicoat® IR, a graft copolymer comprised of polyethylene glycol and polyvinyl alcohol (PEG: PVA, ), has been used as an instant release. Cech T., Kolter K. , Influence of plasticizer on the film properties of HPMC and PVA and comparison of the results with the properties of Kollicoat® IR as.
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Our data demonstrates that the PEG-PVA as a peroxide-free binder can withstand the robust processing conditions and can minimize the risk of oxidative degradation as evident from the data in Table 5.
Binders and their peroxide levels in raloxifene tablets. The aim of this study was to investigate the peroxide free instant release polymer in the instant release matrix tablet and examine the oxidative degradation of raloxifene when used as a wet binder.
The possibilities include the use of antioxidants or smart packaging to alleviate the oxidative degradation [19,20].
Kollicoat® IR: Minimizing the Risks for Oxidative Degradation of Drugs
Subindustry Please choose your subindustry. Granule properties such as particle size and compression profile were evaluated, and compared with copovidone and HMPC granules. Link to reset your password has been sent to your provided E-Mail ID. This water-soluble film-forming agent is ideal for manufacturing instant-release coatings for solid dosage forms — and for applications such as bindingpore forming and drug layering.
The stability data reveal that the peroxide level does not increase at ambient and accelerated stability conditions. Your personal data might be passed on to affiliated companies or third parties.
Controlling the residual peroxides is therefore critical to improve long term stability and to maintain the quality of pharmaceutical dosage forms, and the research continues to find the optimal solutions. Choose your language This site is available in the following languages: Please retry again later. Thus, PEG-PVA with remarkable properties as binder and lr polymer, and free of kollioat, brings a new generation of excipient that could be widely applied to a range of wet granulation formulation development of highly sensitive drugs prone to oxidative degradation.
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Please check your mailbox for further information. Portfolio Overview Focusing on your needs with platform solutions Read. MedCrave Group ie ardent to provide article reprints at an instant affordable Read more This study is aimed at examining the impact of peroxides on degradation of drug in formulations prepared by wet granulation and finds the appropriate excipients to mitigate the risks for degradation. Please provide your registered UserId to reset your password.
Brochure Ensuring the precision you need — every time: Compression profiles of ascorbic acid tablets prepared from the granules prepared by fluid bed and high shear granulations; the compressions were carried out on each individual samples, kolilcoat no statistical data. Composition of raloxifene tablets. Please try again later.
Taken collectively, this study also demonstrates that PEG-PVA was exceptionally stable and did not show a peroxide increase under the various ambient stability conditions over a 5 years period. Wet binder in formulation of ascorbic acid tablet The properties of PEG-PVA as a binder have been evaluated in wet and fluid bed granulations .
Stability condition 3 mo. Looking for application guides, technical and scientific posters, brochures or technical Information? Please provide a kolilcoat registered E-Mail ID. The stability data, as shown in Table 5, suggests that raloxifene tablets with PEG-PVA were stable over 6 month period without degradation.
Please choose your subindustry. Please choose your country. Country Please choose your country. Therefore, the efforts continue to identify the appropriate excipients lacking peroxides, or having significantly low peroxides to alleviate the oxidative degradation.
Based on a work at https: The data from this study demonstrates that PEG-PVA, lacking the inherent residual peroxides as shown in Table 4, curtails the oxidative degradation of raloxifene in the tablets.
In a matrix dosage wherein the drugs and excipients typically are intimately in contact, an elevated level of peroxide may lead to significant oxidation of sensitive drugs, especially those bearing tertiary amines and secondary alcohols. Highly flexible film thanks to integrated plasticizer.
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Thus, minimizing the risks for elevated impurities in the excipients, especially the peroxides, is highly essential, which could otherwise be detrimental to long term stability of pharmaceutical dosages [5 6]. Cookies help us deliver our services. J Anal Pharm Res 2 3: Due to its low viscosity values in aqueous solutions, easy processing in a vast process parameter range is assured. In a subsequent investigation, Yarkala et al. You will find the unsubscribe link at the end of each newsletter you receive.